Table 2.

Baseline Characteristics of European-American Participants by rs1046934 Genotype,^a Cardiovascular Health Study, 1989–1990

	rs1046934 Genotype									P Value
	A/A			A/C			C/C
	Mean (SD)	No.	%	Mean (SD)	No.	%	Mean (SD)	No.	%
Total		1,515	46		1,434	43		360	11
Demographic characteristic
Age, years	72.4 (5.4)			72.2 (5.3)			72.5 (5.6)			0.57
Female sex		901	59		882	62		224	62	0.43
Standing height, cm	164.6 (9.2)			164.5 (9.5)			165.1 (9.2)			0.60
Body mass indexb	26.5 (4.5)			26.2 (4.4)			26.5 (4.6)			0.37
Current smoking		189	13		145	10		37	10	0.32
Risk factor
Diabetes mellitus		193	13		165	12		43	12	0.82
History of myocardial infarction		15	1		10	1		4	1	0.61
History of cerebrovascular accident or stroke		1	0.1		6	0.4		1	0.3	0.15
Use of antihypertension medication		557	37		523	36		116	32	0.26
Physiological measurement
Systolic blood pressure, mm Hg	135.7 (21.2)			134.9 (20.8)			133.6 (21.0)			0.22
Left atrial diameter, cm	3.82 (0.61)			3.81 (0.64)			3.85 (0.63)			0.56
Creatinine concentration, mg/dL	1.01 (0.27)			1.01 (0.27)			1.01 (0.31)			0.97
C-reactive protein concentration, mg/L	3.02 (4.92)			3.26 (6.52)			2.89 (4.31)			0.36
Heart rate, beats/minute	64.5 (9.9)			64.7 (10.3)			65 (10.2)			0.70
Electrocardiographic interval, ms
P-R interval	168.5 (30.9)			165.3 (31.6)			167.4 (31.0)			0.02
QRS interval	91.5 (15.9)			91.2 (15.4)			91.6 (15.9)			0.80
Q-T interval	416.5 (33.0)			416.2 (33.1)			416.7 (33.1)			0.96

Abbreviations: A, adenine; C, cytosine; SD, standard deviation.

^a A is the major allele; C is the minor allele. The frequency of the minor allele in European Americans is 0.33.

^b Weight (kg)/height (m)².