FIG. 4.

Heuristic methods of identifying the molecular mechanisms enabling the transition from an oscillatory state to a differentiated state. (A) In our Notch signaling network model, either constant or pulsating input Delta signal was employed. We changed the values of the each of the 40 parameters and confirmed if the GPU-powered SSA simulation fits our criteria. (B) Selected parameters that had the potential to induce the cell state transition were combined to investigate the binary, ternary, and quaternary combination to induce the cell state transition, but the fold change of each parameter must be less than or equal to 10. GPU, graphics processing unit; SSA, stochastic simulation algorithm.