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. 2014 Jul 1;21(7):548–567. doi: 10.1089/cmb.2014.0022

FIG. 6.

FIG. 6.

Stochastic simulations of Notch signaling in the neural stem cell and the differentiated cell. Trajectory of the Hes1 protein, the Mash1 protein, and the Mash1 mRNA in the neural differentiated cell (input Delta is absent) (A) and the stem cell (input Delta is present) (B, C). In the differentiated cell, the cellular Hes1 protein (Hcp) was kept low and the cellular Mash1 protein (Mcp) was high. In the stem cell, the nuclear Hes1 protein dimer (Hdnp) and the cellular Mash1 mRNA (Mcm) remained oscillatory. The phase difference between Hdnp and Mcm is evident. (C) is a zoomed version of (B).