FIG. 7.

The transition of the Notch signaling pathway from the oscillatory stem cell state to the differentiated cell state—heuristic approach I. For each binary combination of parameters, the simulation trajectory for HCP and MCP after the change of each parameter alone is also shown. “U” indicates that the change was the increase; “D” indicates that the change was the decrease. The fold of change is the numerals that prefixed “U” or “D.” Hcp and Mcp are colored in blue and green, respectively.