. 2014 Jul 1;21(7):548–567. doi: 10.1089/cmb.2014.0022

Table 1.

Sensitivity Analysis of Parameters That Mediate Neural Differentiation

Parameter^a	Definition	Fold change^b	Hcp response^c	Mcp response^c	Input Delta^d
KdHcm (I)	Degradation rate of Hes1 mRNA	100 up	Down	Up	C + P
KdNm (I)	Degradation rate of Notch mRNA	100 up	Down	Up	P
KdNp (I)	Degradation rate of cytoplasmic Notch protein	100 up	Down	Up	P
Ka_r (I)	RBP-Jk NICD dissociation constant	100 up	Down	Up	P
Ka (I)	RBP-Jk NICD association constant	100 down	Down	Up	P
KdHcm (II)	Degradation rate of Hes1 mRNA	10 up		Up	C + P
KdNm (II)	Degradation rate of Notch mRNA	10 up		Up	P
KdNp (II)	Degradation rate of cytoplasmic Notch protein	10 up		Up	P
Ka_r (II)	RBP-Jk NICD dissociation constant	10 up		Up	P
Ka (II)	RBP-Jk NICD association constant	10 down		Up	P
KniHcp (II)	Nuclear transport rate of cytoplasmic Hes1 protein	10 up	Down		C + P
KfNcp (II)	Forward rate of generation of NICD (Ncp) upon binding of Np to input Delta	10 down		Up	P

^{^a}

Parameter that can induce the change of Hcp and Mcp (I, heuristic approach I; II, heuristic approach II; see text).

^{^b}

Fold change of the parameters. Change of all parameters but two parameters (Ka, KfNcp) are increase.

^{^c}

Hcp fell down to less than a fourth of the oscillating one; Mcp increased to more than one-third of the differentiated one.

^{^d}

Input Delta is constant (“C”) or pulsating (“P,” period is 124 min).