. 2014 Jul 1;21(7):548–567. doi: 10.1089/cmb.2014.0022

Table 2.

Binary and Ternary Combination for Parameters Able to Mediate Neural Differentiation

Parameter^a	Parameter^a	Parameter^a	Fold change^b	Input Delta^c	Hcp fold^d	Mcp fold^e
	KdNp	Ka_r	9	P	0.20 (0.02)	0.99 (0.01)
	KdNm	Ka_r	8	P	0.25 (0.03)	0.99 (0.00)
	KdNp	Ka	10	P	0.22 (0.01)	1.00 (0.00)
	KdNm	Ka	10	P	0.14 (0.01)	1.00 (0.00)
	KdNm	KdNp	10	P
Ka_r	KdNm	KdNp	5	P	0.13 (0.02)	1.00 (0.00)
Ka	KdNm	KdNp	7	P	0.12 (0.02)	1.00 (0.00)

^{^a}

Parameters can be combined to induce the cell state transition from stem cell to differentiation (heuristic approach I).

^{^b}

Fold change of the parameters. Change of all parameters but three parameters (Ka) are increase.

^{^c}

Input Delta is constant (“C”) or pulsating (“P,” period is 124 min).

^{^d}

The average ratio of change of Hcp relative to the oscillating Hcp in the stem cell (10 simulations).

^{^e}

The average ratio of change of Mcp relative to the differentiated Mcp in the differentiated cell (10 simulations).