. 2014 Jul 1;21(7):548–567. doi: 10.1089/cmb.2014.0022

Table 3.

Binary, Ternary, and Quaternary Combination for Parameters Able to Mediate Neural Differentiation

Parameter^a	Parameter^a	Parameter^a	Parameter^a	Fold^b	Delta^c	Hcp fold^d	Mcp fold^e
		Ka_r	KniHcp	6	P	0.18 (0.00)	0.37 (0.02)
		KdHcm	KniHcp	5	P	0.24 (0.00)	0.50 (0.01)
		KdNp	KniHcp	7	P	0.15 (0.00)	0.38 (0.02)
		Ka	KniHcp	10	P	0.12 (0.00)	0.54 (0.02)
		KfNcp	KniHcp	10	P	0.11 (0.00)	0.46 (0.02)
		KdHcm	KniHcp	5	C	0.23 (0.00)	0.45 (0.01)
		KdMcm	KniHcp	4, 10^f	P	0.15 (0.00)	0.36 (0.02)
	Ka_r	KdNm	KniHcp	5	P	0.25 (0.01)	0.85 (0.02)
	Ka_r	KdNp	KniHcp	5	P	0.23 (0.01)	0.91 (0.02)
	KdHcm	KdNp	KniHcp	6	P	0.23 (0.00)	0.77 (0.01)
	KdHcm	Ka_r	KniHcp	6	P	0.23 (0.00)	0.79 (0.01)
	KdHcm	KdNm	KniHcp	6	P	0.23 (0.00)	0.71 (0.00)
	KdNp	KdNm	KniHcp	6	P	0.18 (0.01)	0.89 (0.02)
	KdHcm	Ka	KniHcp	6	P	0.22 (0.00)	0.67 (0.01)
	KdHcm	KfNcp	KniHcp	6	P	0.22 (0.00)	0.67 (0.01)
	KdNp	Ka	KniHcp	6	P	0.22 (0.00)	0.70 (0.03)
	KdNp	KfNcp	KniHcp	5	P	0.24 (0.01)	0.51 (0.03)
	Ka_r	KfNcp	KniHcp	6	P	0.23 (0.00)	0.72 (0.01)
	KdNm	Ka	KniHcp	5	P	0.22 (0.00)	0.41 (0.02)
	KdNm	KfNcp	KniHcp	5	P	0.22 (0.00)	0.41 (0.02)
	Ka	KfNcp	KniHcp	6	P	0.18 (0.00)	0.35 (0.02)
KdHcm	KdNm	Ka_r	KniHcp	5	P	0.17 (0.01)	0.96 (0.00)
KdHcm	KdNp	Ka	KniHcp	6	P	0.17 (0.00)	0.94 (0.01)
KdHcm	KdNm	Ka	KniHcp	6	P	0.22 (0.00)	0.86 (0.01)

^{^a}

Parameters can be combined to induce the cell state transition from stem cell to differentiation (heuristic approach II).

^{^b}

Fold change of the parameters. Change of all parameters but three parameters (Ka, KfNcp, and KdMcm) are increase.

^{^c}

Input Delta is constant (“C”) or pulsating (“P,” period is 124 min).

^{^d}

The average ratio of change of Hcp relative to the oscillating Hcp in the stem cell (10 simulations).

^{^e}

The average ratio of change of Mcp relative to the differentiated Mcp in the differentiated cell (10 simulations).

^{^f}

KdMcm: 40% decrease; KniHcp: 10-fold increase.