Table 5.
Potential Molecular Mechanisms That Enable the Cell State Transition
| Parametera | Definition | Mediatorb | Involved mechanismc | Sourced |
|---|---|---|---|---|
| KdHcm | Degradation rate of Hes1 mRNA | miR-9 | mRNA stability | Kiparissides et al. (2011) and this study |
| KdNm | Degradation rate of Notch mRNA | miR-34a | mRNA stability | This study |
| KdNp | Degradation rate of cytoplasmic Notch protein | Numb | Ubiquitination-mediated proteolysis | Barton and Fendrik (2013) and this study |
| Ka | RBP-Jk NICD association constant | Competition | This study | |
| Ka_r | RBP-Jk NICD dissociation constant | Competition | This study | |
| KniHcp | Nuclear transport rate of cytoplasmic Hes1 protein | Nuclear transport | This study | |
| KfNcp | Forward rate of generation of NICD (Ncp) upon binding of Np to Delta | Pin1 | Gamma-secretase activity | This study |
| KdMcm | Degradation rate of Mash1 mRNA | miR-181a | mRNA stablility | Kiparissides et al. (2011) and this study |
| Mash1 cellular protein-E47 dissociation constant | Kiparissides et al. (2011) | |||
| Delta-Notch cis-interaction | Sprinzak et al. (2011), Sprinzak et al. (2010), Shaya and Sprinzak (2011) |
a
Parameters that have the potential to induce the cell state transition from stem cell to differentiation.
b
Possible mediator causing the regulation.
c
The mechanism through which mediator acts.
d
Reference ID.