FIG. 1.

Time course of 4-hydroxy-2-nonenal (4-HNE) after focal controlled cortical impact-traumatic brain injury (TBI) in the mouse. Western blot analysis of 4-HNE in ipsilateral cortex (CTX, A) and hippocampus (HIPP, B) revealed a significant increase in 4-HNE at 48 and 72 hours (in CTX) and at 72 hours and 1 week post-injury (in HIPP) after TBI as compared to sham controls. Analyzed by One-way ANOVA followed by Dunnett's post-hoc test. *=p<.05. Error bars represent±standard deviation. Black box in left most lane indicates the molecular weight range (250 kD to 50 kD) that was included in the densitometry analysis.