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. 2014 Jul 1;31(13):1172–1179. doi: 10.1089/neu.2013.3147

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Copyright 2014, Mary Ann Liebert, Inc.

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FIG. 2. — Intravenous injection of the micelles within 4 h after controlled cortical impact (CCI) improved the function of myelinated and unmyelinated axons of the corpus callosum. (A) Representative traces of compound action potentials (CAPs) evoked at threshold (top traces), 2× threshold (middle traces), and maximum (bottom traces) stimulation intensities in the sham, CCI+vehicle, CCI+0h micelles, and CCI+4h micelles groups. The times of stimulation are marked with black dots. (B,C) Input-output curves of mean N₁ (B) and N₂ (C) peak amplitudes evoked at increasing stimulation intensities in the four groups. CCI resulted in significant decreases in both N₁ and N₂ amplitudes. Injection of the micelles at 0 h or 4 h after injury improved the recovery of N₁ and N₂ amplitudes. **p<0.01, ***p<0.001. Group sizes (mice): Sham=14; CCI+vehicle=11; CCI+0 h micelles=13; CCI+4 h micelles=12.