FIG. 4.

Micelles treatment did not improve resealing of neuronal plasma membrane following controlled cortical impact CCI. (A–D) Two-photon images of cortical (A,B) and hippocampal (C,D) neurons after CCI, which were labeled by ventricular injection of 10 kDa Texas Red-labeled dextran dye. The moderate CCI resulted in membrane disruption and Texas Red-dextran labeling of cortical neurons (A,B) in the vicinity of the injury sites and the dentate granule cells of the hippocampus (C,D). (E,F) There were no significant differences in the number of dye-labeled neurons in either the cortex (E) or hippocampus (F) between the saline+CCI (white bars) and micelles+CCI (black bars) groups (p>0.05). Scale bars: 200 μm in D1 for A1, B1, C1, and D1; 50 μm in D2 for A2, B2, C2, and D2. Group sizes=10–12 mice.