Figure 1.

Removing the gene encoding the β2ARs increases the survival rate in P301S transgenic mice. (A) Breeding diagram illustrating the step-by-step generation of experimental mouse colony beginning with hemizygous P301S mice and homozygous β2KO mouse. (B) Percent survival of each group of experimental mice by age monthly. At the beginning of the experiment, we had n = 20/β2KO; n = 18/β2KO/P301S; n = 12/P301S; n = 17/CTL. While only 66.7% of the P301S mice were still alive at 8 months of age, 88.2% of the β2KO/P301S mice were alive at the same age. (C) Body weight of experimental mice at 8 months of age. Data are presented as means ± SEM and analyzed by ANOVA.