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. 2014 Mar 13;23(15):4024–4034. doi: 10.1093/hmg/ddu116

Figure 2.

Figure 2.

Genetic suppression of β2AR rescues motor strength. Behavioral testing was performed on 8-month-old mice (n = 20/β2KO; n = 15/β2KO/P301S; n = 8/P301S; n = 16/CTL). (A and B) The open-field activity test was conducted to measure spontaneous activity and general motor function. No statistically significant differences were found among the four groups in the distance covered during the exploration time or the speed of movement. (C) To measure motor coordination, we used the accelerating rotarod and found no statistically significant changes among the four groups analyzed. (D) To measure motor strength, we used the hanging wire test and found that the P301S mice were significantly impaired compared with the CTL mice. In contrast, removing the β2ARs from these mice partially rescued this phenotype. Data are presented as means ± SEM and analyzed by ANOVA.