Figure 3.

Wnt1^sw/sw mice have altered biochemical properties in the bone matrix. Biochemical properties of cortical bone as measured by Raman spectroscopy in wild-type (+/+) and Wnt1^sw/sw (sw/sw) mice. The relative quantity of collagen to matrix was measured by the ratio of proline to amide 1 (A). The relative amount of mineral to matrix was measured by the ratio of phosphate to amide (B). The relative amount of mineral to collagen was measured by the ratio of phosphate to proline (C). n = 5 each group, and *P < 0.05; ***P < 0.001.