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. 2014 May 31;86(13):6447–6453. doi: 10.1021/ac500872j

Table 1. Reported Limits of Detection for Various Malaria Diagnostics.

method reported limit of detection converted limit of detection (parasites/μL ⇔ ng/mL)a source
microscopy 20–50 parasites/μL 18–44 ng/mL Moody et al.31 and Guerin et al.32
ELISA 0.1–4 ng/mL roughly 0.1–4.5 parasites/μL Butterworth et al.,33 Dondorp et al.,34 Kifude et al.35
in-lab RDTs (FirstSign–ParaView; SD BIOLINE; Carestart; ICT Malaria Combo Cassette) 6.94–27.75 ng/mL 8–30 parasites/μLa Marquart et al.36
RDTs in the field varies widely; ∼100 parasites/μL ∼90 ng/mL Moody et al.,31 Hendriksen et al.37
a

Calculated on the basis of the model developed by Marquart et al. correlating PfHRP2 concentration to parasite levels, using their maximum circulating approximation: 6.94 ng/mL ∼ 7.8 parasites/μL.36