Table 1. Reported Limits of Detection for Various Malaria Diagnostics.

method	reported limit of detection	converted limit of detection (parasites/μL ⇔ ng/mL)a	source
microscopy	20–50 parasites/μL	18–44 ng/mL	Moody et al.31 and Guerin et al.32
ELISA	0.1–4 ng/mL	roughly 0.1–4.5 parasites/μL	Butterworth et al.,33 Dondorp et al.,34 Kifude et al.35
in-lab RDTs (FirstSign–ParaView; SD BIOLINE; Carestart; ICT Malaria Combo Cassette)	6.94–27.75 ng/mL	8–30 parasites/μLa	Marquart et al.36
RDTs in the field	varies widely; ∼100 parasites/μL	∼90 ng/mL	Moody et al.,31 Hendriksen et al.37

^aCalculated on the basis of the model developed by Marquart et al. correlating PfHRP2 concentration to parasite levels, using their maximum circulating approximation: 6.94 ng/mL ∼ 7.8 parasites/μL.³⁶