Table 2.

Summary results of top independent SNPS in known loci associated with PrCa identified by meta-analysis of ProtecT with UKGPCS

					ProtecT				UKGPCS				Combined (Meta-Results)
SNP	Chroma	Position	Gene	EAF	β	SE	EAFb	P-value	β	SE	EAF*	P-value	β	(95% CI)	P-value	I^2c	P-Hetd
rs12682344	8	128175966	SRRM1P1 -POU5F1B	G	0.57	0.13	0.04	1.28 × 10−05	0.79	0.14	0.04	9.66 × 10−09	0.67	(0.48,0.86)	4.69 × 10−12	21.7%	0.26
rs6983267	8	128482487	SRRM1P1 -POU5F1B	G	0.22	0.05	0.52	4.25 × 10−05	0.36	0.05	0.53	2.30 × 10−12	0.29	(0.22,0.36)	4.04 × 10−15	72.0%	0.06
rs1447295	8	128554220	POU5F1B -MYC	A	0.35	0.08	0.11	2.36 × 10−05	0.67	0.08	0.12	1.20 × 10−16	0.51	(0.40,0.63)	5.61 × 10−18	86.1%	0.01
rs10993994	10	51219502	MSMB	T	0.33	0.06	0.40	1.58 × 10−09	0.46	0.05	0.40	2.15 × 10−19	0.40	(0.33,0.47)	3.48 × 10−26	65.8%	0.09
rs4793529	17	66630231	CALM2P1 -SOX9	T	0.33	0.06	0.47	1.88 × 10−09	0.23	0.05	0.49	8.11 × 10−06	0.28	(0.20,0.35)	1.78 × 10−13	49.8%	0.16
rs17632542	19	56053569	KLK3	T	0.60	0.11	0.91	1.28 × 10−08	0.82	0.08	0.89	4.74 × 10−23	0.73	(0.6,0.86)	2.34 × 10−28	62.7%	0.10

^aChrom - Chromosome

^bEffect Allele Frequency

^c% of variation between study-specific effect estimates which is due to heterogeneity

^dTests the hypothesis that there is no difference in the study-specific effect estimates