Table 1.
Growth inhibition of leukemia and lymphoma cell lines by V158411 and PF-477736
|
Cell line |
p53 status |
GI
50
(μM) ± SD |
Tumor type |
|
|---|---|---|---|---|
| V158411 | PF-477736 | |||
| HL60 |
Mut |
0.21 ± 0.083 |
0.73 ± 0.033 |
Promyelocytic Leukemia |
| Jurkat |
Mut |
0.12 ± 0.07 |
0.12 ± 0.046 |
T-cell Lymphoma |
| K562 |
Mut |
2.8 ± 1.6 |
1.9 ± 1.4 |
Chronic Myelogenous Leukemia |
| MV4-11 |
WT |
0.063 ± 0.033 |
0.13 ± 0.051 |
Acute Monocytic Leukemia |
| Raji |
Mut |
0.42 ± 0.14 |
0.33 ± 0.11 |
Burkett’s Lymphoma |
| U937 | Mut | 0.034 ± 0.018 | 0.099 ± 0.006 | Histiocytic Lymphoma |
Mut, mutant; WT, wild type. GI50 values are the mean of n ≥ 4 ± SD.