Table 1.

MSS and ASN per intervention group (equally-sized groups) for detecting the joint difference for ADAS-Cog (0.2) and ADCS-ADL (0.2), with DF-1 and DF-2 and the overall power of 96% at the one-sided significance level of 2.5%

Decision-making framework	Correlation	Number of analyses	(i) OF-OF		(ii) PC-PC		(iii) OF-PC
			MSS	ASN	MSS	ASN	MSS	ASN
DF-1	0.0	1	804	804	804	804	804	804
		2	808	725	886	607	854	693
		3	816	647	918	572	876	652
		5	825	604	945	548	895	608
		8	832	579	968	535	912	587
		10	840	573	970	530	920	581
	0.3	1	799	799	799	799	799	799
		2	802	702	880	593	850	676
		3	810	633	912	552	870	638
		5	820	589	940	525	890	593
		8	824	563	960	511	904	571
		10	830	556	970	507	910	564
	0.5	1	791	791	791	791	791	791
		2	794	684	872	580	842	662
		3	801	620	903	536	864	627
		5	810	574	930	506	885	582
		8	816	549	952	492	896	558
		10	820	542	960	488	900	551
	0.8	1	764	764	764	764	764	764
		2	768	644	842	549	818	635
		3	774	588	873	501	840	603
		5	785	543	900	469	860	556
		8	792	520	920	453	872	533
		10	800	514	920	447	880	527
DF-2	0.0	1	804	804	804	804	804	804
		2	808	725	882	605	848	690
		3	813	645	912	569	867	646
		5	825	603	940	540	890	602
		8	832	578	960	524	904	579
		10	830	568	960	518	910	572
	0.3	1	799	799	799	799	799	799
		2	802	702	876	591	842	672
		3	807	632	906	549	861	632
		5	815	586	935	520	880	586
		8	824	562	952	503	896	564
		10	830	555	960	498	900	556
	0.5	1	791	791	791	791	791	791
		2	794	684	868	579	834	658
		3	801	620	897	533	855	621
		5	810	574	925	502	875	575
		8	816	549	944	486	888	552
		10	820	541	950	481	890	544
	0.8	1	764	764	764	764	764	764
		2	768	644	840	549	810	631
		3	774	588	870	499	831	597
		5	785	543	895	467	850	550
		8	792	520	912	450	864	528
		10	790	510	920	445	870	521