Table 1.

Transcription factors and reported functions in cortical interneuron development

Transcription factor	Function in cortical interneuron development	Referencesa	Association with human psychiatric/neurological disordersb
ARX	Migration	[55,56]	X-Linked Mental Retardation; X-Linked Lissencephaly with Abnormal Genitalia (mutations); Proud syndrome; Partington syndrome; West syndrome (mutations)
ASCL1 (MASH1)	Neuroepithelial patterning, neurogenesis	[26,57,58]
DBX1	Unknown	[42]
DLX1/2	Inhibition of glial fate, promotion of GABAergic phenotype, migration, differentiation, survival	[26,59–61]	Autism Spectrum Disorder (SNP association)
DLX5/6	Migration, differentiation	[30]	Autism Spectrum Disorder (mutation); Rett Syndrome (epigenetic)
GLI1	Neuroepithelial patterning	[36]
GSX1/2	Neuroepithelial patterning, neurogenesis, cell fate	[35,36,37•]
HMX3 (NKX5.1)	Unknown	[43]
LHX6	Migration, laminar distribution, differentiation	[29,33,34,62]	Schizophrenia (low Lhx6 RNA expression in some patients)
NKX2-1	Neuroepithelial patterning, cell fate, migration	[63–65]
NKX6-2	Neuroepithelial patterning, cell fate	[36,66,67]
NR2F1 (COUPTFI)	Progenitor proliferation	[38]
NR2F2 (COUPTFII)	Migration	[68]
PROX1	Migration, differentiation, maturation	[41•], Miyoshi and Fishell, personal communication
SATB1	Maturation	[53•,54•]
SOX6	Laminar distribution, maturation	[69,70]
SP8	Unknown	[40•]	Bipolar Disorder (locus and intergenic SNP association); Schizophrenia (locus association); Psychosis (locus association)
ZEB2 (SIP1)	Cell fate, migration,	[27•,28•]	Mowat–Wilson syndrome

^aLiterature describing mouse mutants and/or other studies that provide insight into function in cortical interneuron development.

^bAssociation of transcription factors with human psychiatric/neurological disorders reported in the OMIM (Online Mendelian Inheritance in Man), GAD (Genetic Association Database) and Disgenet databases.