Table 2.
Basic Patient Characteristics Before Transplant
| Variable | Edmonton-like protocol | TCD-AI protocol |
P value |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Pt 1 | Pt 2 | Pt 3 | Pt 4 | Pt 5 | Pt 6 | Pt 7 | Pt 8 | ||
| Infusion (n) | 2a | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 0.14c |
| Age | 46 | 57 | 55 | 51 | 38 | 53 | 50 | 35 | 0.15b |
| Sex | M | F | F | F | F | F | F | F | 1.0c |
| Weight (kg) | 79.3 | 59.1 | 80.1 | 65.5 | 54.9 | 75.9 | 52.1 | 54.2 | 0.08b |
| Body mass index | 21.2 | 23.4 | 29.9 | 26.6 | 20.7 | 27.9 | 19.1 | 21.2 | 0.19b |
| Duration of diabetes mellitus (yr) | 23 | 42 | 43 | 38 | 33 | 44 | 40 | 25 | 1.0b |
| Insulin requirement (unit)/day | 46 | 25.5 | 30 | 40 | 24 | 40 | 30 | 24 | 0.24b |
| Insulin requirement (unit)/kg of body weight/day | 0.58 | 0.43 | 0.37 | 0.61 | 0.44 | 0.53 | 0.56 | 0.44 | 1.0b |
| Diabetic complicationsd | None | R, N, K | None | R | R | R, N | None | None | – |
| Hemoglobin A1c (%) | 6.8 | 7.4 | 8.3 | 7.4 | 8.4 | 9.4 | 8.6 | 6.8 | 0.19b |
| SUITO index | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.6 | 0.32b |
| Hypoglycemic unawareness | Y | Y | Y | Y | Y | Y | Y | N | 1.0c |
| Glomerular filtration rate (mL/min) | 121 | 76 | 108 | 128 | 149 | 82 | 100 | 144 | 0.56b |
a
The islets isolated at the remote center were used for initial infusion.
b
Mann-Whitney U test.
c
Fisher’s exact test.
d
R, retinopathy; N, neuropathy; K, nephropathy.