Table 1.
Necropsy results from the mouse longevity studies shown in Fig. 1
| Organ | Pathology | Diet treatment (n) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Control (n = 36)a | Lovaza (n = 35) | Krill oil (n = 35) | |||||||
| No.b | %c | No. | % | P valued | No. | % | P value | ||
| Spleen | Enlarged/tumorous | 23 | 63.9 | 23 | 65.7 | 1.0000 | 20 | 57.1 | 0.6312 |
| Liver | Tumor | 11 | 30.6 | 17 | 48.6 | 0.1488 | 13 | 37.1 | 0.6210 |
| Enlarged/fatty liver | 1 | 2.8 | 1 | 2.9 | 1.0000 | 3 | 8.6 | 0.3570 | |
| Hemangioma | 4 | 11.1 | 1 | 2.9 | 0.3570 | 0 | 0.0 | 0.1145 | |
| Intestinal | Tumor | 5 | 13.9 | 8 | 22.9 | 0.3723 | 4 | 11.4 | 1.0000 |
| Lung | Tumor | 2 | 5.6 | 8 | 22.9 | 0.0457 | 16 | 45.7 | 9.769e-05 |
| Penis | Necrosed/inflamed | 0 | 0 | 2 | 5.7 | 0.2394 | 0 | 0.0 | 1.0000 |
| Seminal vesicles | Enlarged | 1 | 2.8 | 7 | 20.0 | 0.0278 | 3 | 8.6 | 0.3570 |
| Bladder | Distended | 6 | 16.7 | 5 | 14.3 | 1.0000 | 2 | 5.7 | 0.2603 |
| Kidneys | Enlarged/tumorous | 3 | 8.3 | 0 | 0.0 | 0.2394 | 2 | 5.7 | 1.0000 |
| Thymus | Enlarged | 1 | 2.8 | 3 | 8.6 | 0.3570 | 4 | 11.4 | 0.1987 |
| Skin/abdominal cavity | Fibroma | 1 | 2.8 | 1 | 2.9 | 1.0000 | 2 | 5.7 | 0.6142 |
| Peritoneal cavity | Hemorrhage | 4 | 11.1 | 15 | 42.9 | 0.0032 | 12 | 34.3 | 0.0246 |
aNumber of necropsied mice in each treatment group. The necropsied control mice were chosen randomly from among the mice of appropriate ages for approximating the age distribution of the marine oil-treated mice. One mouse from each treatment group was cannibalized and could not be necropsied
bNumber of necropsied mice in each treatment group with the indicated pathologies
cPercent of the necropsied mice in the treatment group with the indicated pathologies
dFisher’s exact test was utilized to investigate the association between the pathologies and treatment groups. The values that were significantly different or near significance are in italics. The P values are two-sided