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Survival curve of rats exposed to hyperoxia. Rats were exposed to >99 % O2 and monitored for survival. Vehicle-treated (glycerol; n = 12), vector-treated (AdV-βGal; n = 6), and sham surgical rats (n = 4) died within 66 h, whereas 66% of Ad5-HO-1–treated rats (n = 12) survived >96 h. Filled triangles: glycerol control; closed squares: AdV-βGal; open squares: sham surgery controls; closed circles: Ad5-HO-1.
