Fig. 3.

Genes associated to a large number of differentially methylated probes do not display a change in gene expression. a 2,390 genes present in the redlined square are associated to 4,554 differentially methylated probes and do not display a change in gene expression (−1 < MA t value < 1). b Relative occurrence of the probe location is presented for all hypo- and hypermethylated differentially methylated probes. c Basal expression of the genes lacking an age-induced change in gene expression is lower than that of genes displaying an age-related change in gene expression. d DNA methylation profile of the SOX1 gene displays age-related hypermethylation, but the expression of this gene is not changed in old compared to young subjects. e Strong hypomethylation was observed in the promoter region of three of the five young subjects, but no change in expression of the DUSP22 gene was detectable