Fig. 5.

WY14,643 treatment of PBMCs induced a strong response in microarray gene expression but caused only a minor effect on DNA methylation. a In response to WY14,643-treatment 2907 probes displayed significant (p < 0.01) differential methylation 4 of which containing over 5 % change between control and Wy-treated samples. These probes were not associated to the 561 genes displaying significant (p < 0.01) differential expression. b Strong induction of FAPB4 expression upon WY treatment. c DNA methylation of the six probes representing the highest PPARα-response gene FABP4 on the 450K array did not show a change in DNA methylation upon WY14,643 treatment