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Desmosterol/cholesterol ratio in rat serum, cortex and hippocampus
| Desmosterol/cholesterol | 12 months | 24 months | ||
|---|---|---|---|---|
| AL | DR | AL | DR | |
| Serum | 1.13 ± 0.13 | 1.79 ± 0.23* | 1.08 ± 0.08 | 3.56 ± 0.56* |
| Cortex | 4.75 ± 0.51 | 3.9 ± 0.31 | 3.68 ± 0.30 | 3.88 ± 0.30 |
| Hippocampus | 6.98 ± 0.77 | 9.70 ± 0.48 | 6.05 ± 0.35 | 8.03 ± 0.51* |
Data are expressed μg/mg cholesterol (serum) and ng/μg cholesterol (brain)
*P < 0.05 vs. the age-matched control
