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Characterization of an additional mutation (Q281R) that causes partial PAF acetylhydrolase deficiency. (a) The sequence of a mutation found in an asthmatic subject is shown. The Q281R mutation maps near the active site. (b) Immunoblot showing expression of the Q281R mutant in E. coli. (c) PAF acetylhydrolase activity determination of the Q281R mutant protein and its comparison with the wild type and with the vector control.
