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Characterization of a polymorphism (I198T) that has no effect on PAF acetylhydrolase activity. (a) The sequence of a polymorphism found in asthmatic subjects that also harbored the V279F mutation is shown. (b) Immunoblot showing expression of the I198T mutant in E. coli. (c) PAF acetylhydrolase activity determination of the I198T mutant protein and its comparison to the wild type and to the vector control.
