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. 2014 Jun 19;15(1):496. doi: 10.1186/1471-2164-15-496

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© Zysset-Burri et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Cellular component analysis of potential pathogenicity factors from N. fowleri. Gene Ontology (GO) graph generated from the cellular component ontology of the proteins, which were up-regulated in highly pathogenic trophozoites compared to weakly pathogenic trophozoites. The specificity of the GO terms increases from the bottom to the top of the graph with arrows indicating “being part of”. The majority of the potential pathogenicity factors localize to the membrane of the cell (blue marked circles), whereas another group of proteins localized to either cell projections (green marked circles) or vesicles (orange marked circles).