Figure 4. Forest plot of a subset of studies in the discovery phase with at least ten events for rs4458204_A annotated to the CCL20 gene.
We found no evidence of heterogeneity in the per-allele HR across 14 studies (I2=0%, P for heterogeneity=0.84). P-value for both fixed and random effects meta-analyses on all 14 studies was 3.93 × 10−7, whereas on this reduced data set (studies with <10events excluded for clarity of presentation) it was 1.76 × 10−6, which passes the preset Bonferroni threshold of 2.29 × 10−5 for 2,184 independent tests. The 95% confidence interval for each study is given by a horizontal line, and the point estimate is given by a square whose height is inversely proportional to the s.e. of the estimate. The summary odds ratio is drawn as a diamond with horizontal limits at the confidence limits and width inversely proportional to itss.e.