Table 3.
Cases | Person- Yearsa |
Age-adjusted HR (95% CI) |
Multivariate- adjusted HRb (95% CI) |
Multivariate- adjusted HRc (95% CI) |
|
---|---|---|---|---|---|
Psoriasis | |||||
No hypercholesterolemia | 427 | 1,006,906 | 1.00 | 1.00 | 1.00 |
Hypercholesterolemia with no medication | 180 | 276,817 | 1.45 (1.21, 1.73) | 1.28 (1.07, 1.53) | 1.26 (1.05, 1.51) |
Hypercholesterolemia with regular statins use | 36 | 34,805 | 1.75 (1.22, 2.50) | 1.36 (0.95, 1.95) | 1.21 (0.83, 1.76) |
Hypercholesterolemia with regular other cholesterol-lowering drugs use | 7 | 4,361 | 2.62 (1.23, 5.57) | 2.05 (0.96, 4.38) | 1.78 (0.83, 3.83) |
Psoriasis with concomitant PsA | |||||
No hypercholesterolemia | 93 | 1,002,575 | 1.00 | 1.00 | 1.00 |
Hypercholesterolemia with no medication | 60 | 275,541 | 2.11 (1.52, 2.95) | 1.64 (1.17, 2.29) | 1.62 (1.15, 2.27) |
Hypercholesterolemia with regular statins use | 11 | 34,687 | 2.22 (1.15, 4.30) | 1.40 (0.72, 2.72) | 1.23 (0.62, 2.44) |
Hypercholesterolemia with regular other cholesterol-lowering drugs use | 2 | 4,351 | 3.21 (0.78, 13.2) | 1.94 (0.47, 8.03) | 1.65 (0.39, 6.95) |
Person-years of hypercholesterolemia with no medication, statins use, and other cholesterol-lowering drugs use did not add up to total hypercholesterolemia person-years because a small proportion of participants used statins and other drugs simultaneously.
Simultaneously adjusted for age, BMI (<24.9, 25–29.9, 30–34.9, and ≥35 kg/m2), alcohol intake (no, <5.0, 5.0–9.9 or ≥10.0 g/d), physical activity (<3.0, 3.0–8.9, 9.0–17.9, 18.0–26.9 or ≥27.0 metabolic equivalent hours/week), and smoking status (never, past, current smoking with 1–14, 15–24, or ≥25 cigarettes/day).
Additionally adjusted for cardiovascular disease (yes or no), type 2 diabetes (yes or no), and hypertension (yes or no).