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. 2014 May 13;11:9. doi: 10.1186/1742-4933-11-9

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Copyright © 2014 Lanzer et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Age-associated changes in T cell receptor Vβ distribution in CD4 and CD8 naïve and activated/memory T cells in specific pathogen free mice. T cell receptor Vβ usage was assessed among distinct populations of CD44^high (activated/memory) or CD44^low (naïve) CD4 and CD8 T cells in individual young and aged mice. The proportion of cells from 5 young or 10 aged mice bearing individual T cell receptor Vβ elements was determined by staining with a panel of anti-Vβ antibodies, and is represented by different colors, which are the same order in the key and individual samples. Panel A shows the Vβ distribution among CD44^high CD8 T cells. Panel B shows the Vβ distribution among CD44^high CD4 T cells. Panel C shows the Vβ distribution among CD44^low CD8 T cells. Panel D shows the Vβ distribution among CD44^low CD4 T cells. Statistical analysis is described in the text.