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. 2014 Jun 13;16:10. doi: 10.1186/1480-9222-16-10

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Copyright © 2014 Cheluvappa; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Biological markers of inflammation and immunity correlating with our murine model of appendicitis (and appendectomy) [24],[25]. Appendicitis and appendectomy performed in the most proximal colon induce gene expression changes to curb T helper 17 cell activities, curtail autophagy, modulate interferon activity-associated molecules, and suppress endothelin vasoactivity-mediated immunopathology/vascular remodelling in the most distal colon. These contribute to the limitation/amelioration of colitis pathology.