Table 2.

Distances in the active site that change along the reaction coordinate and/or among the mutants.

	Wt		G121V		M42W		G121V-M42W
	Reactant	TS	Reactant	TS	Reactant	TS	Reactant	TS
DAD	3.65 ± 0.16	2.64 ± 0.06	3.66 ± 0.15	2.63 ± 0.06	3.63 ± 0.17	2.64 ± 0.06	3.62 ± 0.16	2.64 ± 0.06
A7 N-NADP O7	3.23 ± 0.24	2.99 ± 0.14	3.75 ± 0.50	3.08 ± 0.23	3.30 ± 0.27	2.95 ± 0.12	3.57 ± 0.43	3.14 ± 0.20
A7 O-NADP N7	3.02 ± 0.19	3.00 ± 0.19	3.40 ± 0.41	3.12 ± 0.28	3.06 ± 0.23	2.94 ± 0.16	3.24 ± 0.38	3.02 ± 0.22
I14 O-NADP N7	3.30 ± 0.29	3.66 ± 0.33	3.14 ± 0.26	3.43 ± 0.32	3.04 ± 0.21	3.08 ± 0.22	3.08 ± 0.22	3.14 ± 0.25
M20 S-DHF N5H	3.54 ± 0.46	2.81 ± 0.28	3.57 ± 0.47	3.05 ± 0.41	3.68 ± 0.40	3.12 ± 0.36	3.85 ± 0.55	3.32 ± 0.39