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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: J Immunol. 2014 Jun 18;193(2):571–579. doi: 10.4049/jimmunol.1400043

FIGURE 2. High and low affinity TCRs are able to accumulate in the pancreas and induce spontaneous diabetes development.

FIGURE 2

(A) Frequencies of insulin specific T cells in the infiltrated pancreatic islets were obtained from analysis of TCR retrogenic mice 7-8 weeks post bone marrow transfer. An average of at least 10 mice from 4 separate experiments is shown. Error bars represent SEM.

(B and C) Histological assessment of insulitis in insulin TCR retrogenic mice at 8-9 weeks post bone marrow transfer.

(D) TCR retrogenic mice were monitored for spontaneous diabetes development (n ≥ 20 mice per group).