Table 2.

Whole Brain Volumes Represent Raw Values

	CW, n = 22		AN, n = 19
Whole Brain Volumes	Mean	SD	Mean	SD	t	p-value
Gray Matter Volume (cm3)	667.38	68.33	662.62	44.88	0.243	0.809
White Matter Volume (cm3)	472.28	45.53	459.79	44.91	0.881	0.383
Cerebral Spinal Fluid Volume (cm3)	252.35	49.23	230.74	24.16	1.739	0.09
Total Intracranial Volume (cm3)	1392.02	86.5	1353.16	91.81	1.388	0.173
Regional Gray Matter Volume Contrasts AN Adolescents > Controls	MNI Coordinates		Cluster Size	T/Z	Cluster Level pFWE-corr	Peak Level pFWE-corr
L Middle Orbitofrontal Cortex	−33, 60, −9		189	4.21/3.75	0.011	0.009
R Fusiform Gyms	20, −34, −15		137	5.43/4.57	0.001	0.032
R Fusiform Gyms	27, −10, −36		107	4.88/4.22	0.005	0.042
L Fusiform Gyms	−32, −7, −41		100	4.26/3.79	0.024	0.047
R Hippocampus	29, −27, −8		113	4.74/4.12	0.003	0.018
L Hippocampus	−33, −19, −11		74	4.01/3.61	0.018	0.026
R Insula	41,5,7		69	4.06/3.64	0.029	0.047
R Parahippocampal Gyrus	18, −10, −29		579	6.41/5.15	<0.001	0.001
L Parahippocampal Gyrus	−21, −13, −27		116	4.42/3.90	0.008	0.021
L Gyrus Rectus	−5, 30, −26		19	3.99/3.59	0.014	0.038
L Gyrus Rectus	−9, 30, −26		25	3.95/3.56	0.016	0.035
L Gyrus Rectus	−6, 53, −24		41	4.19/3.73	0.009	0.028
Regional White Matter Volume Contrasts AN Adolescents > Controls	MNI Coordinates		Cluster Size	T/Z	Cluster Level pFWE-corr	Peak Level pFWE-corr
R Hippocampus	29, −21, −20		208	5.60/4.68	<0.001	0.007
R Parahippocampal Gyrus	29, −25, −20		237	5.74/4.76	<0.001	0.006
R Middle Temporal Gyrus	50, −31, −6		82	5.98/4.91	0.001	0.078
L Superior Temporal Gyrus	−48, −33, 22		98	3.86/3.49	0.071	0.045

Note: Regional brain volume contrasts based on group comparison corrected for total intracranial volume, age, comorbid diagnoses and medication use. AN=anorexia nervosa; CW=control adolescents; FWE-corr=family-wise error corrected; L=left; MNI=Montreal Neurological Institute; R=right.