Table 4.
Micronucleus test results in mice treated with whole extract of Xanthium strumarium L.
| Dose (mg/kg) | Female | Male | ||
|---|---|---|---|---|
| PCE/NCEa ± SD | MNPCE/2000b ± SD | PCE/NCEa ± SD | MNPCE/2000b ± SD | |
| 0 | 0.46 ± 1.32 | 0.18 ± 0.43 | 0.35 ± 1.39 | 0.20 ± 0.24 |
| 500 | 0.07 ± 1.57 | 0.03 ± 0.08 | 0.10 ± 1.70 | 0.03 ± 0.11 |
| 1000 | 0.28 ± 1.58 | 0.06 ± 0.08 | 0.16 ± 1.51 | 0.03 ± 0.07 |
| 2000 | 0.08 ± 1.46 | 0.03 ± 0.11 | 0.07 ± 1.46 | 0.03 ± 0.11 |
| Ethanolc | 0.05 ± 1.39 | 0.01 ± 0.08 | 0.32 ± 1.45 | 0.04 ± 0.08 |
| CPd | 0.06 ± 0.63∗∗ | 1.80 ± 7.62∗∗ | 0.07 ± 0.53∗∗ | 0.75 ± 5.38∗∗ |
aPCE/NCE: polychromatic (PCE) to normochromatic (NCE) erythrocyte ratio; bMNPCE/2000: frequency of micronucleated PCE; cNegative control: ethanol 60%; dPositive control: cyclophosphamide 20 mg/Kg. ∗∗P < 0.01 (Student's t-test).