Figure 9.
Clotting time at different initial concentrations of factor VIII. The reference value is 7.00 · 10−10 M (dashed black line); the sweep range is [7.00 · 10−16, 7.00 · 10−4]. The blue area indicates a condition in which factor VIII concentration is less than 1% of its physiological concentration, corresponding to a situation of severe haemophilia; the red area indicates a condition in which factor VIII concentration is between 1% and 30% of its physiological concentration, corresponding to a situation of mild haemophilia; the green area indicates a condition in which factor VIII concentration is greater than 130% of its physiological concentration, corresponding to a situation of hypercoagulability.