Table 1.
Reaction-based model of the blood coagulation cascade (reduced version of the “Platelet-Plasma” model described in [30]). The model consists in 96 reactions among 71 molecular species. With the exception of reaction r 44 (see Section 3.1), the values of all reaction constants were taken from [30].
| n | Reactants | Products | Constant (k) |
|---|---|---|---|
| r 1 | TF + fVII | TF-fVII | 3.20 · 106 M−1 s−1 |
| r 2 | TF-fVII | TF + fVII | 3.10 · 10−2 s−1 |
| r 3 | TF + fVIIa | TF-fVIIa | 2.30 · 107 M−1 s−1 |
| r 4 | TF-fVIIa | TF + fVIIa | 3.10 · 10−5 s−1 |
| r 5 | TF-fVIIa + fVII | TF-fVIIa + fVIIa | 4.40 · 105 M−1 s−1 |
| r 6 | fXa + fVII | fXa + fVIIa | 1.30 · 107 M−1 s−1 |
| r 7 | fIIa + fVII | fIIa + fVIIa | 2.30 · 104 M−1 s−1 |
| r 8 | TF-fVIIa + fX | TF-fVIIa-fX | 2.50 · 107 M−1 s−1 |
| r 9 | TF-fVIIa-fX | TF-fVIIa + fX | 1.05 · 10−2 s−1 |
| r 10 | TF-fVIIa-fX | TF-fVIIa-fXa | 6.00 s−1 |
| r 11 | TF-fVIIa-fXa | TF-fVIIa + fXa | 19.00 s−1 |
| r 12 | TF-fVIIa + fXa | TF-fVIIa-fXa | 2.20 · 107 M−1 s−1 |
| r 13 | TF-fVIIa + fIX | TF-fVIIa-fIX | 1.00 · 107 M−1 s−1 |
| r 14 | TF-fVIIa-fIX | TF-fVIIa + fIX | 2.40 s−1 |
| r 15 | TF-fVIIa-fIX | TF-fVIIa + fIXa | 1.80 s−1 |
| r 16 | fII + fXa | fIIa + fXa | 7.50 · 103 M−1 s−1 |
| r 17 | fIIa + fVIII | fIIa + fVIIIa | 2.00 · 107 M−1 s−1 |
| r 18 | fVIIIa + fIXa | fIXa-fVIIIa | 1.00 · 107 M−1 s−1 |
| r 19 | fIXa-fVIIIa | fVIIIa + fIXa | 1.00 · 10−4 s−1 |
| r 20 | fIXa-fVIIIa + fX | fIXa-fVIIIa-fX | 1.00 · 108 M−1 s−1 |
| r 21 | fIXa-fVIIIa-fX | fIXa-fVIIIa + fX | 1.00 · 10−5 s−1 |
| r 22 | fIXa-fVIIIa-fX | fIXa-fVIIIa + fXa | 8.20 s−1 |
| r 23 | fVIIIa | fVIIIa1-L + fVIIIa2 | 6.00 · 10−5 s−1 |
| r 24 | fVIIIa1-L + fVIIIa2 | fVIIIa | 2.20 · 104 M−1 s−1 |
| r 25 | fIXa-fVIIIa-fX | fVIIIa1-L + fVIIIa2 + fX + fIXa | 1.00 · 10−3 s−1 |
| r 26 | fIXa-fVIIIa | fVIIIa1-L + fVIIIa2 + fIXa | 1.00 · 10−3 s−1 |
| r 27 | fIIa + fV | fIIa + fVa | 2.00 · 107 M−1 s−1 |
| r 28 | fXa + fVa | fXa-fVa | 4.00 · 108 M−1 s−1 |
| r 29 | fXa-fVa | fXa + fVa | 0.2 s−1 |
| r 30 | fXa-fVa + fII | fXa-fVa-fII | 1.00 · 108 M−1 s−1 |
| r 31 | fXa-fVa-fII | fXa-fVa + fII | 103.00 s−1 |
| r 32 | fXa-fVa-fII | fXa-fVa + fmIIa | 63.50 s−1 |
| r 33 | fXa-fVa + fmIIa | fXa-fVa + fIIa | 1.50 · 107 M−1 s−1 |
| r 34 | fXa + TFPI | fXa-TFPI | 9.00 · 105 M−1 s−1 |
| r 35 | fXa-TFPI | fXa + TFPI | 3.60 · 10−4 s−1 |
| r 36 | TF-fVIIa-fXa + TFPI | TF-fVIIa-fXa-TFPI | 3.20 · 108 M−1 s−1 |
| r 37 | TF-fVIIa-fXa-TFPI | TF-fVIIa-fXa + TFPI | 1.10 · 10−2 s−1 |
| r 38 | TF-fVIIa + fXa-TFPI | TF-fVIIa-fXa-TFPI | 5.00 · 107 M−1 s−1 |
| r 39 | fXa + ATIII | fXa-ATIII | 1.50 · 103 M−1 s−1 |
| r 40 | fmIIa + ATIII | fmIIa-ATIII | 7.10 · 103 M−1 s−1 |
| r 41 | fIXa + ATIII | fIXa-ATIII | 4.90 · 102 M−1 s−1 |
| r 42 | fIIa + ATIII | fIIa-ATIII | 7.10 · 103 M−1 s−1 |
| r 43 | TF-fVIIa + ATIII | TF-fVIIa-ATIII | 2.30 · 102 M−1 s−1 |
| r 44 | fXII | fXIIa | 5.00 · 10−4 s−1 |
| r 45 | fXIIa + fXII | fXIIa-fXII | 1.00 · 108 M−1 s−1 |
| r 46 | fXIIa-fXII | fXIIa + fXII | 750.00 s−1 |
| r 47 | fXIIa-fXII | fXIIa + fXIIa | 3.30 · 10−2 s−1 |
| r 48 | fXIIa + PKal | fXIIa-PKal | 1.00 · 108 M−1 s−1 |
| r 49 | fXIIa-PKal | fXIIa + PKal | 3.60 · 103 s−1 |
| r 50 | fXIIa-PKal | fXIIa + Kal | 40.00 s−1 |
| r 51 | fXII + Kal | fXII-Kal | 1.00 · 108 M−1 s−1 |
| r 52 | fXII-Kal | fXII + Kal | 45.30 s−1 |
| r 53 | fXII-Kal | fXIIa + Kal | 5.70 s−1 |
| r 54 | PKal + Kal | Kal + Kal | 2.70 · 104 M−1 s−1 |
| r 55 | Kal | Kali | 1.10 · 10−2 s−1 |
| r 56 | fXIIa + C1inh | fXIIa-C1inh | 3.60 · 103 M−1 s−1 |
| r 57 | fXIIa + ATIII | fXIIa-ATIII | 21.60 M−1 s−1 |
| r 58 | fXI + fIIa | fXI-fIIa | 1.00 · 108 M−1 s−1 |
| r 59 | fXI-fIIa | fXI + fIIa | 5.00 s−1 |
| r 60 | fXI-fIIa | fXIa + fIIa | 1.30 · 10−4 s−1 |
| r 61 | fXIIa + fXI | fXIIa-fXI | 1.00 · 108 M−1 s−1 |
| r 62 | fXIIa-fXI | fXIIa + fXI | 200 s−1 |
| r 63 | fXIIa-fXI | fXIIa + fXIa | 5.70 · 10−4 s−1 |
| r 64 | fXIa + fXI | fXIa + fXIa | 3.19 · 106 M−1 s−1 |
| r 65 | fXIa + ATIII | fXIa-ATIII | 3.20 · 102 M−1 s−1 |
| r 66 | fXIa + C1inh | fXIa-C1inh | 1.80 · 103 M−1 s−1 |
| r 67 | fXIa + A1AT | fXIa-A1AT | 1.00 · 102 M−1 s−1 |
| r 68 | fXIa + A2AP | fXIa-A2AP | 4.3 · 103 M−1 s−1 |
| r 69 | fXIa + fIX | fXIa-fIX | 1.00 · 108 M−1 s−1 |
| r 70 | fXIa-fIX | fXIa + fIX | 41.00 s−1 |
| r 71 | fXIa-fIX | fXIa + fIXa | 7.70 s−1 |
| r 72 | fIXa + fX | fIXa-fX | 1.00 · 108 M−1 s−1 |
| r 73 | fIXa-fX | fIXa + fX | 0.64 s−1 |
| r 74 | fIXa-fX | fIXa + fXa | 7.00 · 10−4 s−1 |
| r 75 | fXa + fVIII | fXa-fVIII | 1.00 · 108 M−1 s−1 |
| r 76 | fXa-fVIII | fXa + fVIII | 2.10 s−1 |
| r 77 | fXa-fVIII | fXa + fVIIIa | 0.023 s−1 |
| r 78 | fVIIa + fIX | fVIIa-fIX | 1.00 · 108 M−1 s−1 |
| r 79 | fVIIa-fIX | fVIIa + fIX | 0.90 s−1 |
| r 80 | fVIIa-fIX | fVIIa + fIXa | 3.60 · 10−5 s−1 |
| r 81 | fVIIa + fX | fVIIa-fX | 1.00 · 108 M−1 s−1 |
| r 82 | fVIIa-fX | fVIIa + fX | 210.00 s−1 |
| r 83 | fVIIa-fX | fVIIa + fXa | 1.60 · 10−6 s−1 |
| r 84 | Fbg + fIIa | Fbg-fIIa | 1.00 · 108 M−1 s−1 |
| r 85 | Fbg-fIIa | Fbg + fIIa | 636.00 s−1 |
| r 86 | Fbg-fIIa | Fbn1 + fIIa + FPA | 84.00 s−1 |
| r 87 | Fbn1 + fIIa | Fbn1-fIIa | 1.00 · 108 M−1 s−1 |
| r 88 | Fbn1-fIIa | Fbn1 + fIIa | 742.60 s−1 |
| r 89 | Fbn1-fIIa | Fbn2 + fIIa + FPB | 7.40 s−1 |
| r 90 | Fbn1 + Fbn1 | (Fbn1)2 | 1.00 · 106 M−1 s−1 |
| r 91 | (Fbn1)2 | 2Fbn1 | 6.40 · 10−2 s−1 |
| r 92 | (Fbn1)2 + fIIa | (Fbn1)2-fIIa | 1.00 · 108 M−1 s−1 |
| r 93 | (Fbn1)2-fIIa | (Fbn1)2 + fIIa | 701.00 s−1 |
| r 94 | (Fbn1)2-fIIa | (Fbn2)2 + fIIa + FPB | 49.00 s−1 |
| r 95 | Fbn2 + fIIa | Fbn2-fIIa | 1.00 · 108 M−1 s−1 |
| r 96 | Fbn2-fIIa | Fbn2 + fIIa | 1.00 · 103 s−1 |