Figure 4.
Effect of S. aureus-derived PAMPs on SEB-induced systemic inflammatory response syndrome in vivo. HLA-DR3 transgenic mice were challenged with staphylococcal enterotoxin B (SEB) alone (50 μg), staphylococcal peptidoglycan (PGN) alone (50 μg), or heat-killed Staphylococcus aureus (HKSA) alone (108 bacteria), SEB with PGN or SEB with HKSA. Animals bled 4 hours after injection and serum cytokines were quantified using Bioplex assays (Bio-Rad). Mean ± SE from 4–6 mice in each group. *P < 0.05 compared to naïve mice.