Table 7.
Calculation of costs of posttreatment anticancer therapy.
| Treatment | Medication costa | Administration costsb | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mg per tab or vial | Cost per tab or vial, £ | Cost per mg, £ | Cost per administration, £ | Expected days of use per course | Cost per course of therapy, £ | Cost per administration, £ | Expected days of use per course | Cost per course of therapy, £ | Total cost per course of therapy, £ |
|
| Cyclophosphamide | 500 | 6 | 0 | 30 | 6.14 | 187 | 330 | 6.14 | 2,027 | 2,214 |
| Dacarbazine | 1,000 | 32 | 0 | 68 | 3.35 | 229 | 205 | 3.35 | 686 | 915 |
| Doxorubicin | 200 | 275 | 1 | 181 | 2.85 | 515 | 205 | 2.85 | 583 | 1,098 |
| Etoposide | 100 | 12 | 0 | 13 | 30.68 | 400 | 205 | 30.68 | 6,280 | 6,681 |
| Etoposide + ifosfamide (+mesna) | ||||||||||
| Etoposide | 100 | 12 | 0 | 13 | 26.30 | 343 | 205 | 26.30 | 5,383 | — |
| Ifosfamide | 1,000 | 44 | 0 | 217 | 15.78 | 3,430 | 302 | 15.78 | 1,539 | — |
| Mesna | 400 | 4 | 0 | 46 | 15.78 | 725 | — | 15.78 | — | — |
| Total | — | — | — | — | — | 4,499 | — | — | 6,922 | 11,421 |
| Gemcitabine | 1,500 | 214 | 0.14 | 197 | 13.57 | 2,674 | 205 | 13.57 | 2,778 | 5,451 |
| Gemcitabine + docetaxel (+lenograstim) | ||||||||||
| Gemcitabine | 1,500 | 214 | 0.14 | 185 | 8.90 | 1,643 | 205 | 8.90 | 1,821 | — |
| Docetaxel | 140 | 720 | 5.14 | 676 | 4.45 | 3,007 | — | 4.45 | — | — |
| Lenograstim | 0.263 | 62.54 | 238 | 64 | 31.14 | 1,988 | 0.57 | 31.14 | 18 | — |
| Total | — | — | — | — | — | 6,639 | — | — | 1,839 | 8,478 |
| Ifosfamide (+mesna) | ||||||||||
| Ifosfamide | 1,000 | 44 | 0 | 217 | 15.78 | 3,430 | 302 | 15.78 | 4,769 | — |
| Mesna | 400 | 4 | 0 | 46 | 15.78 | 725 | — | 15.78 | — | — |
| Total | — | — | — | — | — | 4,156 | — | — | 4,769 | 8,924 |
| Sorafenib | 200 | 27 | 0 | 71 | 114.37 | 8,096 | 12 | 4.08 | 49 | 8,145 |
| Sunitinib | 12.5 | 28 | 2 | 99 | 65.33 | 6,489 | 12 | 1.56 | 19 | 6,508 |
| Temozolomide | 250 | 136 | 0.54304 | 109 | 23.67 | 2,570 | 12 | 0.85 | 10 | 2,580 |
| Trabectedin | 1 | 1,366 | 1,366 | 3,167 | 3.40 | 10,768 | 330 | 3.40 | 1,123 | 11,891 |
Tab: tablet; aunit costs of medications based on British National Formulary [32, 35]; bfacility costs for administration of intravenous therapies are based on a weighted average of the outpatient, day case, and other 2010/2011 NHS Reference Costs for delivery of a chemotherapy cycle (SB12Z deliver simple parenteral chemotherapy at first attendance, and SB14Z deliver complex chemotherapy, including prolonged infusional treatment at first attendance for infusion of more than 24 hours) [35]. Assume dispensing costs of oral medications are based on the cost of a community pharmacist (15 minutes) [34].