MR imaging–guided prostate biopsy. Photographs (top) and computer screens (bottom) showing the use of an MR imaging–compatible biopsy device. The device (top left) has an endorectal probe (arrow), a needle guide (arrowhead), and a set of dials (D) that which allow the needle to be directed to the target on the basis of input from the targeting software (bottom left). The software provides the necessary angles for probe rotation, needle angulation, and needle depth (bottom right). The dials are adjusted manually by the operator based on the software’s calculations, which are derived from pre-biopsy MR images. The patient is placed in the prone position (top right), and the biopsy probe is placed endorectally (arrow at bottom right). Reprinted with permission from (19).