TABLE 2.

Percent of Weeks in Remission, in Subthreshold States, or in Episode During Study Years 1 and 2 for Adolescents With Bipolar Disorder Receiving Pharmacotherapy With Either Family-Focused Treatment or Enhanced Care^a

Clinical State	Family-Focused Treatment				Enhanced Care
	Year 1 (N=53)		Year 2 (N=40)		Year 1 (N=58)		Year 2 (N=49)		p
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Treatment	Time	Treatment by time
Euthymic	47.1	25.9	56.4	32.0	51.2	27.7	57.6	28.9	0.56	0.01	0.63
Subthreshold mood (depressed or manic/hypomanic)	36.1	20.7	26.3	22.5	33.1	20.8	30.4	24.8	0.90	0.02	0.17
Syndromal mood (depressed or manic/hypomanic)	16.9	12.2	17.0	19.3	15.7	15.0	12.1	12.9	0.19	0.33	0.28
No depressive symptoms	63.0	27.9	63.4	32.0	62.7	29.4	69.1	25.8	0.56	0.25	0.31
Subthreshold depressive symptoms	25.8	21.2	22.1	21.3	25.3	22.5	21.5	20.3	0.89	0.11	0.99
Syndromal depressive episode	11.2	10.5	14.4	19.3	12.0	13.9	9.3	11.7	0.30	0.87	0.07
No manic/hypomanic symptoms	71.7	25.2	85.4	18.9	78.1	21.6	82.4	22.8	0.66	<0.001	0.048
Subthreshold manic/hypomanic symptoms	22.4	21.9	11.5	17.6	17.2	14.9	14.2	22.4	0.70	0.004	0.09
Syndromal manic/hypomanic episode	6.0	8.2	3.0	5.0	4.7	9.1	3.3	6.9	0.69	0.03	0.40

Treatment effects are based on mixed-effects regression models with time (year 1 or 2) as the within-subject factor, treatment group as the between-subject factor, a group-by-time interaction, and a subject-level random effect to account for correlations between the repeated measurements. Covariates included study site, baseline Mania or Depression Rating Scale scores from the Schedule for Affective Disorders and Schizophrenia for School-Age Children, living situation (with two biological parents or not), and number of weeks of follow-up. Means, standard deviations, and p values are adjusted for covariates. Analyses excluded participants who had less than 6 months of follow-up.