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. 2014 Jan 6;74(4):778–785. doi: 10.1136/annrheumdis-2013-203759

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This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

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Reduced IL-10 receptor expression in B6.SLE T_reg and T_eff populations. Whole splenocytes were obtained from 6-month-old mice and examined for surface expression of the IL-10R by flow cytometry. Samples were gated on CD4⁺ cells, and then the cell populations of interest were examined. (A) Contour plots showing IL-10R expression on CD4⁺FoxP3⁻ (left) and CD4⁺FoxP3⁺ (right) cells from B6 (top) and B6.SLE (bottom) mice. (B) Quantification showing the proportion of each cell population expressing IL-10R. (C) Quantification of the mean fluorescence intensity of IL-10R staining on T_reg and T_eff populations. Data are representative of at least six mice per group. * Indicates significance at p<0.05. SLE, systemic lupus erythematosus.