Table 2.

Baseline and operative characteristics of the cohort

Baseline Characteristics	Cohort Subset (n=422)
Gender, n (%)
Female	176 (41.7%)
Male	246 (58.3%)
Ethnicity, n (%)
Asian/Pacific Islander, Hispanic, or other ancestry	51 (12.1%)
African ancestry, not Hispanic	98 (23.2%)
European ancestry, not Hispanic	273 (64.7%)
Gestational Age, weeks, mean ± SD	38.5 ± 2.05
Gestational Weight, kg, mean ± SD	3.15 ± 0.62
Diagnostic Class, n (%)
I: 2 ventricles, no arch obstruction	204 (48.3%)
II: 2 ventricles, arch obstruction	41 (9.7%)
III: 1 ventricle, no arch obstruction	46 (10.9%)
IV: 1 ventricle, arch obstruction	131 (31.1%)
Specific CHD Diagnoses, n (%)
Hypoplastic Left Heart Syndrome	130 (30.8%)
Tetralogy of Fallot	64 (15.2%)
Transposition of the Great Arteries	34 (8.1%)
Ventricle Septal Defect	40 (9.5%)
Ventricle Septal Defect, Coarctation of Aorta	19 (4.5%)
Single Ventricle	30 (7.1%)
Other Distinct CHD Diagnoses	105 (24.9%)
Preoperative intubation, n (%)	119 (28.2%)
Preoperative length of stay, days, mean ± SD	2.14 ± 2.61
Age at first operation, days, mean ± SD	42.1 ± 54.7
Weight at first operation, kg, mean ± SD	3.82 ± 1.25
Total cardiopulmonary bypass time in first operation, min, mean ± SD	67.1 ± 40.3
Use of DHCA, n (%)	259 (61.4%)
Total DHCA time in first operation, min, mean ± SD	41.4 ± 18.3
Hematocrit level after hemodilution in first operation, %, mean ± SD	27.8 ± 4.1
Genetic risk score categorya
0 risk alleles	11 (2.6%)
1 risk allele	64 (15.2%)
2 risk alleles	138 (32.7%)
3 risk alleles	150 (35.5%)
4 risk alleles	59 (14.0%)
Long-term mortality, n (%)	47 (11.1%)
Time to mortality, years, mean ± SD	9.32 ± 3.48
Heart Transplants, n (%)	4 (1.0%)

CHD = congenital heart defect. DHCA = deep hypothermic circulatory arrest.

^aNumber of VEGFA SNP rs833069 or SOD2 SNP rs2758331 major alleles, which are both associated with worse long-term survival.