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. 2014 Jun 30;15:24. doi: 10.1186/1471-2121-15-24

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Copyright © 2014 Verma et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CNX-011-67 is a specific agonist of GPR40. CNX-011-67 induced GPR40 activation was measured in GPR40 over-expressing CHOK1 cells by its potency to increase in cytoplasmic calcium level which was abolished by PLC inhibitor (U73122) (n = 4, ***P < 0.001). CNX-011-67 did not increase any cytoplasmic calcium level in cells not expressing GPR40.