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. 2014 Jul 1;28(13):1410–1428. doi: 10.1101/gad.240895.114

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© 2014 Pezic et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 7. — Model for piRNA-induced establishment of the H3K9me3 mark on L1 elements. Transcripts from a full-length LINE in the nucleus of embryonic prospermatogonia are recognized by a MIWI2–piRNA complex, which recruits a histone methyltransferase (HMTase). This results in deposition of the H3K9me3 mark on LINE 5′ repeats and in the adjacent upstream region. The piRNA associates only with transcripts from actively transcribed copies of TEs. Truncated copies, which are not transcribed, are not targeted by piRNAs.