Table II. Percentage of newly synthesized guanidine-soluble ECM proteins extracted from control and bleomycin-induced fibrotic lung tissue after 1 and 3 weeks of label. Values represent mean ± S.D. (n = 3) where protein data were available from three distinct biological samples.

Protein	UniProt accession number	Average F control, 1 week (%)	Average F bleomycin, 1 week (%)	Average F control, 3 weeks (%)	Average F bleomycin, 3 weeks (%)
Agrina	A2ASQ1	11.1 ± 0.5	14.0 ± 2.7	30.7 ± 0.3	64.4 ± 6.9
Biglycanb	P28653	65.8 ± 4.2	86.7 ± 5.1	85.1 ± 2.2	95.9 ± 2.1
Collagen α-1(I) chainb	P11087	10.3 ± 1.7	21.4 ± 4.9	17.9 ± 2.4	52.7 ± 3.2
Collagen α-2(I) chaina	Q01149	10.3 ± 1.5	17.9 ± 3.2	17.6 ± 2.6	53.8 ± 2.3
Collagen α-1(V) chainc	O88207	9.9 ± 2.4	25.3 ± 8.0	47.0	62.7
Collagen α-2(V) chainc	Q3U962	7.6 ± 0.1	27.2 ± 6.4	20.4 ± 4.3	58.7
Collagen α-1(VI) chainb	Q04857	6.7 ± 1.0	18.3 ± 1.8	14.5 ± 0.1	58.9 ± 11.4
Collagen α-2(VI) chaina	Q02788	9.3	19.1 ± 1.7	15.7 ± 1.6	62.1 ± 10.7
Decorin	P28654	89.6	N/A	N/A	98.4
Dermatopontinb	Q9QZZ6	7.2 ± 1.0	22.3 ± 6.2	16.4 ± 1.4	64.3 ± 5.9
Fibronectinb	P11276	77.4 ± 2.9	96.2 ± 3.0	76.4 ± 2.5	94.7 ± 2.3
Laminin subunit α-4a	P97927	20.7 ± 8.1	24.6 ± 4.8	44.9 ± 1.4	69.2 ± 4.2
Laminin subunit α-5b	Q61001	8.6 ± 1.9	21.8 ± 1.0	23.5 ± 3.2	51.9 ± 4.0
Laminin subunit β-1b	P02469	13.9 ± 2.6	31.5 ± 6.9	45.6 ± 7.3	81.1 ± 8.7
Laminin subunit β-2a	Q61292	16.8 ± 3.7	25.5 ± 4.7	39.1 ± 1.1	70.9 ± 4.5
Laminin subunit γ-1a	P02468	14.0 ± 0.7	23.3 ± 2.0	42.2 ± 1.3	67.4 ± 3.8
Microfibril-associated glycoprotein 4a	Q9D1H9	8.1 ± 0.6	11.7 ± 3.6	22.7 ± 3.1	61.0 ± 3.3
Nidogen-1a	P10493	16.3 ± 1.3	25.7 ± 5.0	44.2 ± 1.5	74.2 ± 4.8
Nidogen-2a	O88322	9.4 ± 1.1	13.0 ± 4.7	28.6 ± 1.0	49.3 ± 10.1
Perlecanb	Q05793	22.5 ± 1.2	33.3 ± 7.3	51.5 ± 1.5	79.9 ± 1.9
Prolargin	Q9JK53	55.5	78.5 ± 6.8	76.6 ± 10.2	99.1
Protein–glutamine γ-glutamyltransferase 2b	P21981	44.7 ± 2.2	63.3 ± 6.3	86.2 ± 2.3	97.5 ± 2.4

^a p < 0.05 at 3 weeks only.

^b p < 0.05 at both time points.

^c p < 0.05 at 1 week only.