Table I. Summary of the proteomic results obtained in the SILAC-SPROX experiments to characterize the CsA binding properties of the proteins in a yeast cell lysate.

SILAC-SPROX experiment	Total Lys-containing peptides (proteins) identified	Total Lys- and Met-containing peptides (proteins) identified	Total peptides (proteins) assayed for bindinga	Hit peptides (Proteins)
Control (No Ligand)	1471 (546)	415 (203)	119 (58)	4 (4)
CsA Binding Exp. 1	982 (429)	298 (144)	69 (25)	3 (2)
CsA Binding Exp. 2	1149 (493)	328 (165)	104 (48)	2 (1)

^a Includes peptides (and the proteins to which they map) that were successfully identified and quantified in samples from at least four denaturant concentrations.