Table 2.

Concentrations of pepsinogen I, pepsinogen II, and pepsinogen I to II ratio according to the severity of histological categories¹ in antrum and corpus in first-degree relatives of patients with gastric adenocarcinoma before H. pylori eradication (n = 371).

			Pepsinogen I (μg/mL)		Pepsinogen II (μg/mL)		Pepsinogen ratio
			Median	IQR2	Median	IQR	Median	IQR
Antrum	Neutrophil cell infiltration	High n = 221	109.1	83.6–160.8	16.3∗	10.5–24.3	6.8	5.0–9.4
		Low n = 148	105.3	74.1–154.9	14.0	9.2–21.6	7.5	5.3–10.3
	Mononuclear cell infiltration	High n = 323	106.2	81.8–157.4	15.8∗	10.2–23.9	7.0	5.2–9.4
		Low n = 46	117.9	66.7–168.2	11.6	9.0–20.7	8.3	4.1–13.5
	Atrophy	High n = 76	100.3	74.6–158.0	16.4	10.4–23.0	6.2∗	5.0–8.7
		Low n = 293	109.1	81.9–158.7	15.0	9.8–23.7	7.5	5.2–10.4
	Intestinal metaplasia	High n = 32	89.8	64.9–152.3	15.4	11.4–19.9	6.0∗	4.1–8.0
		Low n = 337	108.3	82.1–160.2	15.3	9.7–23.9	7.2	5.2–10.0
Corpus	Neutrophil cell infiltration	High n = 194	109.2	85.4–156.6	17.1∗∗∗	11.3–26.5	6.4∗∗∗	4.7–8.4
		Low n = 175	104.6	76.4–162.4	13.0	8.9−20.3	8.0	5.6–11.2
	Mononuclear cell infiltration	High n = 276	105.9	79.2–157.0	17.0∗∗∗	10.6−25.5	6.5∗∗∗	4.7–8.5
		Low n = 93	112.5	80.3–161.1	11.6	8.7−18.0	9.1	6.4–13.1
	Atrophy	High n = 107	103.0	77.8–162.6	17.2∗	11.4−24.7	6.2∗∗	4.7–8.6
		Low n = 262	108.4	80.9–157.9	14.2	9.5−23.2	7.5	5.3–10.5
	Intestinal metaplasia	High n = 14	184.4	58.8–263.2	24.9∗	13.5−41.9	5.1∗	4.1–8.2
		Low n = 355	106.9	79.7–155.5	15.0	9.9−23.4	7.1	5.2–10.0

¹Low score: normal or mild changes; high score: moderate or marked changes.

²IQR: interquartile range expressed as percentile 25–75.

∗ P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 when pepsinogen concentrations (or pepsinogen ratio) were compared in groups of high and low histology scores (Mann-Whitney U test).